E. Bonaparte1,2, M. Moretti1, G.M. Colpi3, F. Nerva3, G. Contalbi3, L. Vaccalluzzo3, S. Tabano1, F.R. Grati2, G. Gazzano4, S.M. Sirchia1, G. Simoni2, A. Gallina5,*, and M. Miozzo1
1Department of Medicine, Surgery and Dentistry, Medical Genetics Unit, Universita` degli Studi di Milano, 20142 Milano, Italy 2Research and Development, Cytogenetics and Molecular Biology, TOMA Advanced Biomedical Assays SpA, 21052 Busto Arsizio, Italy 3Andrological- Urology Unit and IVF Center, Azienda Ospedaliera San Paolo, 20142 Milano, Italy 4Pathology Unit, Azienda Ospedaliera San Paolo, 20142 Milano, Italy 5Department of Medicine, Surgery and Dentistry, Applied Biology Unit, Universita` degli Studi di Milano, 20142 Milano, Italy
*Correspondence address. Tel: +39-02-50323209; Fax: +39-02-50323211; E-mail: andrea.gallina@unimi.it
Hum Reprod. 2010 Jun;25(6):1398-403
It would be of value to identify ongoing spermatogenesis molecular markers which can predict successful sperm recovery in patients with non-obstructive azoospermia undergoing conventional or microsurgical testicular sperm extraction (TESE/microTESE). ESX1 is an X-linked homeobox gene expressed in testis, placenta, brain and lung in humans and specifically in pre- and post-meiotic germ cells of the testis in mice.
ESX1 emerges as a potentially reliable spermatogenesis molecular marker, whose clinical value as a predictor of successful sperm retrieval warrants further studies.
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